Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development

Authors: Roy Helmy, Brian Musselman, Wes Schafer, Leah Buhler, Stephen Marcinko, Erin Guidry, Herb Jenkins, Fred Fleitz, Christopher Welch
Org. Process Res. Dev. 2010, Feb, 10, 14 (2), 386–392
DOI: 10.1021/op9002938


The use of ambient pressure desorption ionization mass spectrometry
for the rapid analytical support of process and pharmaceutical
development is demonstrated. The ability of direct analysis in real
time (DART®) technology to analyze both active pharmaceutical
ingredients (APIs) and intermediates without sample preparation or the
development of LC-based separations provided critical experimental
results with minimal time required for method development. The utility
and versatility of DART® is shown for applications such as degradation
studies, analysis of high-throughput catalyst screens, preparative-
scale chromatography fractions, and impurity determination.
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